How and When to Take Amitriptyline
In general, amitriptyline should be taken one time a day. Drowsiness is a possible side effect of this drug. Therefore, it is advisable to take the medication before bedtime. In case you still feel sleepy in the morning, consider taking it earlier at night. You may take amitriptyline with or without food as it does not often cause stomach upset. The medication may taste a bit bitter when you chew the pill. The liquid form is available with a plastic spoon or syringe to measure the right dosage. Avoid using a kitchen teaspoon as it can be hard to take the right amount of amitriptyline. [4]
How Amitriptyline Works
Amitriptyline works similarly to other antidepressants. It boosts the number of neurotransmitters in the brain, especially norepinephrine and serotonin. Both chemicals play an important part in regulating pain, mood, and well-being. Serotonin is especially involved in the process of controlling blood vessels during a migraine attack. By increasing the levels of these two chemicals, amitriptyline can help reduce the frequency and intensity of migraine headaches. [5]
