Possible Interactions with Verzenio
The liver releases an enzyme named CYP3A to break down and remove Verzenio from the body. Certain medications would affect the activity of this enzyme and thus impact how Verzenio works. For instance, CYP3A inhibitors, such as ketoconazole or clarithromycin may slow the elimination of Verzenio from the body. This increases the drug’s possible side effects. In contrast, CYP3A inducers like modafinil, efavirenze, or rifampin may speed up the removal of Verzenia, thus reducing the drug’s effectiveness. To reduce the risk, it is important to inform your doctor about other medications that you are taking. You should avoid taking Verzenio with grapefruit or grapefruit juice as it would increase the side effects. [9]
