Ailments & ConditionsYour Health

Main Causes of Low Platelets

Thrombocytes or platelets are a kind of blood cells in the body. When the skin gets broken or injured, these components will help form clots and stop bleeding by clumping together. When you suffer from low platelets, however, there will be not enough platelet cells in the blood for this process. As a result, it might lead to many fatal issues and severe bleeding, depending on the underlying reasons. With that in mind, the following sections will show you 10 main causes of low platelets.


Many medications could lead to low platelets count. NSAIDs or nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin, Advil), naproxen, and aspirin might thin the blood and reduce your platelet count. Heparin, a blood thinner, is the most common trigger of drug-induced thrombocytopenia as it encourages the body to generate excessive antibodies that can destroy platelets.

Some other medications that would cause this health issue include proton-pump inhibitors, H2 blockers, panobinostat, isotretinoin, interferon, carboplatin, methotrexate, valproic acid, and some antibiotics. However, do not stop taking any drugs without the guidance of your doctor.[1]