Causes
The precise cause of stiff person syndrome is still unclear. However, many scientists suggest that it is possibly genetic. The risk can also be higher when you have a family history of other forms of autoimmune diseases, such as vitiligo, thyroiditis, rheumatoid arthritis, pernicious anemia, as well as type 1 and type 2 diabetes.
In people with stiff person syndrome, glutamic acid decarboxylase antibodies are produced to attack other proteins in the brain neurons, which are responsible for muscle movements. The exact symptoms can vary, depending on the affected areas. [4]
