Study Discovers Effect of Exercise on Metabolism

A group of Brazilian scientists has found out that aerobic exercise stimulates the production and release of microRNAs into the bloodstream. These components can provide more energy for the muscles.

Previous studies have suggested that the production of microRNAs, which are signaling molecules, can be affected by obesity and aging. This may increase the risk of metabolic illnesses, such as dyslipidemia and diabetes.

The finding indicates that exercise can help with the production of microRNAs, thus preventing these diseases.

The study is published in the Proceedings of the National Academy of Sciences of the United States of America.

In the research, scientists in Sao Paulo, Brazil, cooperated with researchers at Harvard University and the University of Copenhagen.

They put mice for 1 hour each day in 8 weeks on a treadmill. Once these animals became fitter, they increased the treadmill’s slope and speed.

At the end of the experiments, scientists noticed a noticeable increase in the release of DICER, a protein in the mice’s fat cells. This is associated with drops in visceral fat and body weight.

By allowing for more microRNAs to be produced, DICER helps the body generate more energy for muscles.

When the experiment was repeated with genetically modified mice that could not produce DICER in fat cells, the training program did not provide many benefits.

In other words, their fat cells did not provide muscles with sufficient energy during intense exercise. This is because more glucose is consumed without DICER. This may result in low levels of blood sugar or hypoglycemia, which eventually lowers the performance of athletes.

When the same experiment was conducted on human participants, scientists noticed a 5-time increase in the amount of DICER after 6 weeks in high-intensity interval training.

Workout improved levels of DICER in these individuals, both young and old. Nevertheless, the exact amount varied, which would explain why the effects of exercises are not the same for everyone.

In addition, researchers also injected blood serum, extracted from a mouse undergone exercises, into one that had not. The main purpose was to verify that signaling molecules could help with the communication of muscle and fat.

They noticed that the infusion boosted the release of DICER in the recipient mouse. This indicates that trained people have one or more molecules that can have direct effects on metabolic improvement.

Scientists concluded that this metabolic flexibility plays an important role in performance improvement and good health.

Source:

https://www.pnas.org/content/117/38/23932

Related Articles

Common Causes of Narcissism You Should Know

Ailments & Conditions
Narcissism is a form of personality disorder that makes people have inflated opinions of themselves. Also, these individuals have an intense need for others’...

15 Powerful Benefits of Spinach You Do Not Know

Diet & Nutrition
Originated from Persia, spinach is a very popular leafy green veggie. It is in the amaranth family, along with quinoa and beets. The greatest...

Why Is My B12 Level High?

Your Health
Vitamin B12 is a water-soluble vitamin with many important functions in the body, from brain health and nerve operation to red blood cell and...

Medtronic Recalls Insulin Pumps Increasing the Risk of Incorrect Dosing

Your Health
Medtronic, a medical device firm, is recalling some kinds of insulin pumps because it has just detected a dangerous defect that would have a...

Study Finds Coffee Consumption May Lower Risk of Liver Condition

Health News
Coffee is one of the most popular drinks in the world. Yet, there are many contradictory scientific results on both risks and benefits of...

12 Causes of Congestive Heart Failure

Ailments & Conditions
Congestive heart failure is a serious condition that affects millions of people around the world. You can have this problem on the right side,...

Causes & Risk Factors for Pancreatitis

Ailments & Conditions
Pancreatitis happens when the pancreas, a large organ located behind the stomach, gets swollen and inflamed. This condition might lead to many health issues...

15 Causes of Leg Pain You Need to Know

Ailments & Conditions
Leg pain is a very common health issue for non-athletes and athletes alike. In most cases, mild or minor leg pain is often caused...